Inside the Microbiome-Endocannabinoid Axis
Inside the Microbiome-Endocannabinoid Axis
The gut is home to a complex communication network that integrates neural, immune, and microbial inputs to maintain gastrointestinal health.
Welcome to the Association of Cannabinoid Specialists' Doc Talk Blog, where you'll find the most up-to-date science, news, advocacy, and updates from cannabinoid specialists and other experts in the fields of cannabinoid medicine, policy, industry, education, and more.

The gut is home to a complex communication network that integrates neural, immune, and microbial inputs to maintain gastrointestinal health.

Love, sex, and cannabis make an appealing Valentine’s trio—but, like any good ménage à trois, they work best with clear communication, low drama, and correct dosing.

Medical cannabis use from an Islamic perspective is a nuanced subject balancing religious principles, the prohibition of intoxication, and the therapeutic benefits of cannabis.

Spain’s inclusion of standardized magistral (compounded) cannabinoid preparations in the National Formulary is a meaningful regulatory milestone that brings much‑needed national consistency, quality standards, and traceability to prescribed cannabis medicines.[1][2][3]

Cannabis has a long-standing role in medicine and recently the United States Department of Health and Human Service (HHS) has declared it meets the standard of Commonly Accepted Medical Use (CAMU). Modern research has revealed its effectiveness and safety for multiple conditions. The United States Food and Drug Administration (FDA) has approved cannabinoid-based drugs for many years, and evidence suggests that current non-pharmaceutical cannabis products may offer even greater efficacy. Despite this, a majority of physicians are not fully aware of the therapeutic possibilities cannabinoids provide and often feel hesitant to prescribe them, even when patients could benefit.

Cannabis is often touted as being a “cure-all” or panacea for a wide range of illnesses from chronic pain to anxiety to cancer to insomnia and others. Not only is this thinking medically invalid, it undermines the legitimate use of cannabinoid medications.

On December 18, 2025 the United States government definitively declared “Cannabis IS Medicine”. Association of Cannabinoid Specialists (ACS) has been advocating that position since our physician-founder established our non-profit.

The rise of cannabis-based medicine across Africa is reshaping how nations think about health, policy, and economic opportunity. Southern Africa presents a fascinating spectrum, from Zimbabwe’s export-driven approach to South Africa’s cautiously progressive model and Mauritius’s newly regulated framework.

Disclaimer: This article was written in large part with the assistance of AI. While the basic tenets are familiar to me, as a fairly secular Jew, I claim no deep insight into the nuances of Jewish law.
Medical cannabis use within the Jewish perspective is approached thoughtfully through halakhic (Jewish law) and ethical frameworks that emphasize the sanctity of life, health, and moral living.

A large number of cannabis and hemp industry advocacy groups as well as cannabis clinician groups have been emailing last week to “save hemp” in light of the federal budget that would re-criminalize “intoxicating hemp” products. At ACS we disagree with the positions both factions have taken.

Cannabinoids, particularly THC and CBD, are increasingly considered for managing symptoms associated with autism spectrum disorder (ASD), and the Association of Cannabinoid Specialists recognizes both the promise and limitations of current research in this area.

Discussing medical cannabis use with family during gatherings such as Thanksgiving can be a sensitive and emotional topic.

Imagine a young adult reaches for a cannabinoid vape pen (e.g., CBD, CBG, Δ⁹-THC, Δ⁸-THC) before a stressful exam, hoping it will calm their anxiety. Another patient takes a quick puff for fast relief from chronic pain or insomnia.

Halloween and cannabis can both bring a little magic to the season—but mix them carelessly, and that charm can turn spooky real fast. Whether you’re doling out treats, heading to a costume party, or just settling in for a scary movie night, it’s worth taking a few precautions to keep the holiday fun and safe for everyone (yes, even the family’s candy goblins).

ACS’ Board Members are actively involved in many aspects of the medical field. For example, ACS Director and attorney, Bryant Godfrey of Foley Hoag, hosted a Life Sciences conference at the firm’s Boston offices. Pictured here is Bryant interviewing the CEO of the Reagan-Udall Foundation for the FDA, Susan Winckler, in a “fireside chat” style conversation.
Should Medical Cannabis Patients Grow Their Own Cannabis?
When considering whether medical cannabis patients should grow their own medicine, the conversation must be grounded in evidence, compassion, and rooted in real clinical experience.

As clinicians specializing in cannabinoid medicine, we are often asked about the use of cannabis for psychiatric conditions, including bipolar disorder.

Dear Mr. President,
We are writing to respectfully urge your administration to finalize the rescheduling of marijuana from Schedule I to Schedule III.

Cannabis can play a meaningful and supportive role in the care of patients undergoing cancer treatment. However, it is essential that cannabis be used judiciously, with attention to dosing, formulation, and individual patient context. Too often, cannabis is portrayed as a miracle cure, when in fact, its real value lies in alleviating specific symptoms and improving quality of life.

To improve quality of care in cannabis medicine, healthcare providers must be properly educated and held to the same ethical standard of informed consent required in all medical practice. Boards of Registration for Medicine, Nursing, and Pharmacy bear the responsibility to enforce these standards and ensure compliance among their members.

Telemedicine offers a vital opportunity to improve patient access, convenience, and quality of cannabis care, especially in underserved or rural areas where specialist care may be limited.

Living with a rheumatological condition often means dealing with chronic pain, inflammation, and other debilitating symptoms. These conditions can drastically impact quality of life, and while conventional treatments often help, they don’t always provide complete relief.

For decades, women, researchers, and clinicians have consistently reported that cannabis enhances female orgasmic response —yet this consistent finding has received little attention in mainstream medicine or clinical training.

The Association of Cannabinoid Specialists (ACS) asserts that rigid lists of qualifying conditions for medical cannabis use are medically inappropriate and restrict access to evidence-based care. State laws that dictate which conditions are eligible for treatment with cannabis undermine the professional judgment of physicians and reduce the flexibility necessary to respond to evolving scientific evidence.

As medical and recreational cannabis use becomes increasingly legal across various jurisdictions, clinicians are increasingly confronted with questions from patients about traveling with cannabis. The legal complexities, medical risks, and potential consequences of transporting cannabis across borders—both domestic and international—are significant. It is essential for clinicians to understand these issues in order to offer accurate, up-to-date guidance to patients who rely on cannabis for therapeutic purposes.

Cannabinoids—compounds derived from the cannabis plant and produced endogenously—are increasingly being studied for their potential to treat neurological disorders. Their therapeutic value lies in their ability to interact with the endocannabinoid system (ECS), which plays a key role in maintaining homeostasis across several physiological systems, including those governing pain perception, mood regulation, memory, and neuroinflammation.

Insomnia is one of the most common sleep disorders, affecting up to 30% of the population10 . It is characterized by difficulty falling or staying asleep, with symptoms occurring at least three times per week for three months or more.

On June 22, 2025, Texas’ Governor Greg Abbott vetoed Senate Bill No. 3, "Relating to the regulation of products derived from hemp, including consumable hemp products and the hemp-derived cannabinoids contained in those products; requiring occupational licenses and permits; imposing fees; creating criminal offenses; authorizing an administrative penalty."

In the realm of medical research, particularly within the context of cannabinoids, the reliance on human-based evidence over animal or cell studies holds paramount importance.

Delta-8 tetrahydrocannabinol (Delta-8 THC) is a cannabinoid gaining traction as a legal alternative to Delta-9 THC, the primary compound in cannabis. While both share structural similarities, Delta-8 is often described as a “milder” version of Delta-9. However, clinicians should be aware that this perceived safety may be misleading. Delta-8 has distinct biological effects, manufacturing-related hazards, and a growing record of adverse events, many of which remain under-recognized in clinical practice.